Anastrozole: How This Breast Cancer Drug Can Slow Progression of the Disease

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Anastrozole: How This Breast Cancer Drug Can Slow Progression of the Disease


What is Anastrozole?

Anastrozole is a drug used to treat breast cancer. It is an aromatase inhibitor. Aromatase inhibitors are drugs that inhibit the production of estrogen in the body. Estrogen can promote the growth of some types of breast cancer cells. Anastrozole was first approved by the US Food and Drug Administration (FDA) in 1996 for the treatment of breast cancer in postmenopausal women who had been diagnosed with early-stage disease. In 2005, it was approved for use by women with the advanced-stage disease who were no longer responding to other treatments, such as tamoxifen or letrozole. Anastrozole is also given to men with prostate cancer who are not eligible or do not respond to androgen deprivation therapy. Anastrozole is a selective estrogen receptor modulator (SERM) and has been shown in clinical trials to be effective in the treatment of breast cancer. Anastrozole was initially thought to affect only the breast, but it was later found to also have a stimulatory effect on the uterus (and thus ovaries) and on the pituitary gland.Anastrazole is an aromatase inhibitor. It reduces estrogen and progesterone levels in men by blocking the aromatase enzyme. This is useful in treating gynecomastia caused by hormonal therapy.

See also about main goal of Anastrozole

What types of side effects does Anastrozole cause?

Anastrozole can cause side effects such as:


  • Aching or pain in the joints and muscles
  • Menopausal symptoms
  • Low mood and depression
  • Difficulty sleeping
  • Fatigue (extreme tiredness)
  • Osteoporosis (thinning of the bone)

Other side effects of anastrozole include:

  • Headaches, nausea, and vomiting
  • High cholesterol
  • Loss of appetite
  • Constipation or diarrhea
  • Carpal tunnel syndrome
  • Hair and skin changes
  • Vaginal bleeding
  • Liver changes
  • Dizziness

Anastrozole’s side effects and how to deal with them

Anastrozole’s side effects

A large number of persons see a reduction in adverse effects during the first few months after beginning medication. However, for some individuals, they may be distressing and create disruptions in their daily lives.

If you have any adverse effects, whether or not they are stated here, you should see your doctor or treatment team. They may be able to provide suggestions on methods to alleviate your discomfort.

Because some women respond better to a different aromatase inhibitor, such as letrozole or exemestane, or to another hormone therapy, your doctor may recommend switching to a different medicine.

In addition, your breast care nurse may be able to provide assistance and support.

Side effects that are common

Inflammation or discomfort in the joints and muscles

Aching or discomfort in the joints and muscles is usually minor and transient, however, it may be more severe and linger for a longer period of time in certain persons.

In most cases, modest pain relievers such as paracetamol or anti-inflammatory medications such as ibuprofen may be used to alleviate the symptoms. Before using anti-inflammatory pain relievers, consult with your doctor about the proper dosage, how long you should take them for, and any potential side effects, particularly if you have a stomach ulcer or suffer from asthma or allergies.

Yoga or pilates, for example, may be beneficial in alleviating your discomfort since they gently stretch your joints and develop your muscles to better support your joints. A physiotherapist may also be able to provide exercises that would be beneficial. If you have secondary breast cancer, you should consult with your doctor before beginning any new sort of physical activity.

If your pain is severe, your physician may recommend that you see a rheumatologist (a doctor who has a special interest in joint and muscle pain). It may also be beneficial to visit a pain clinic and speak with a pain management professional.

Some patients find that switching to a different hormone medication is beneficial. For example, it may be feasible to switch to a different aromatase inhibitor to see if your discomfort improves, or the medicine tamoxifen may be recommended as an option for certain women with breast cancer.

Menopausal symptoms

If you are going through menopause, you may experience menopausal symptoms such as hot flushes, excessive sweating, sleep disturbances, vaginal irritation such as dryness and itching, and a decrease in sexual desire (sex drive). Many individuals report that their symptoms gradually improve over time.

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Learn more about menopause symptoms, sex and intimacy, and other topics.

Depression and a depressed mood

Some folks are sad or down in the dumps. If you are experiencing these symptoms, it might be difficult to determine whether they are caused by the medicine or by other factors such as menopausal symptoms or coping with the diagnosis of cancer.

Consult with your doctor or treatment team for advice on how to deal with a change in mood. Counseling or mindfulness might be beneficial for certain individuals. Others have discovered that exercise enhances their mood. Your general practitioner or specialist may send you for counseling or may recommend that you take antidepressant medication.

Your breast care nurse may also be able to provide you with help or provide you with information about support programs available in your region.

Sleeping problems

Sleeping problems (insomnia) may be alleviated by doing some easy things like reducing coffee intake in the afternoon and evening, keeping your room dark and quiet, and going to bed and waking up at the same time every day.

Exercises that promote relaxation might also be beneficial. There are a variety of resources available, including CDs, podcasts, and smartphone applications, to help you learn these methods.

If your insomnia is severe and chronic, your doctor may recommend that you take a sleeping pill.

Extreme exhaustion

Physical exercise, according to research, may aid to alleviate weariness and fatigue-related symptoms. Learn more about weariness and how to deal with it effectively.

Complementary therapy may also be beneficial for certain individuals.

When using anastrozole, some individuals report feeling tired or sleepy-like.

Osteoporosis is a disease that affects the bones (thinning of the bone)

Anastrozole works by lowering the quantity of estrogen in the body’s tissues. Osteoporosis is caused by a loss of estrogen over a period of time.

It is possible that your specialist may do a bone density scan before or soon after you begin taking anastrozole to assess the strength and thickness of your bone (bone density).

In the course of your treatment with anastrozole, your bone density may need to be examined every two to three years, depending on the findings of the first scan and whether or not your doctor has any concerns.

It is possible to boost your calcium and vitamin D consumption in order to help maintain your bones strong. The majority of folks do this by taking a supplement. Also, foods high in calcium, such as milk, cheese, yogurt, and cereals, may be beneficial to your overall health and wellness.

You may improve your intake of vitamin D by eating more fatty fish, mushrooms, and eggs in general.

Smoking should be avoided, and regular resistance training should be performed to maintain your bones as strong as possible.

Find out more about how to take care of your skeleton.

If your bones are already starting to show indications of weakening or if you have osteoporosis, you may be prescribed additional medication to help boost bone density and strength even more. This is commonly a medicine from a class of medications known as bisphosphonates. If you are worried about this, it may be beneficial for you to discuss it with your doctor.

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Other side effects may occur.

Headaches, nausea, and vomiting are all possible side effects.

Headaches, nausea, and vomiting are all possible side effects of anastrozole. Over time, these conditions normally improve or become simpler to manage. Headaches may be alleviated by using mild pain relievers such as paracetamol. It is beneficial to take anastrozole with or after eating to help minimize nausea.

Cholesterol levels are high.

Anastrozole may induce a spike in the amount of cholesterol in the blood, while this is typically not a problem that requires treatment. If you have a family history of elevated cholesterol, you should consult with your specialist or general practitioner.

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Appetite loss

If you are experiencing appetite loss, it may be beneficial to take your medication with meals. It is possible that eating small, frequent meals or snacks can help you maintain your caloric intake. If you are having difficulty maintaining a healthy weight, speak with your doctor or specialist about being referred to a dietician for assistance.

Learn more about the relationship between nutrition and breast cancer therapy.

Constipation or diarrhea

It is essential to drink enough water if you are suffering from constipation or diarrhea. Constipation may be alleviated by maintaining an active lifestyle and eating a high-fiber diet.

Medications to relieve constipation or diarrhea might be prescribed by your general practitioner or specialist.

Carpal tunnel syndrome

Carpal tunnel syndrome is characterized by discomfort, tingling, coldness, and weakness in the hand and forearm. If you are experiencing any of these symptoms, you should see your doctor or a specialist.

Changes in the appearance of the hair and skin

While using anastrozole, it is possible that you could have some hair loss or thinning. When you stop taking anastrozole, your hair should revert to the condition it was in before therapy. Females who see an increase in downy facial hair are in the minority.

Some individuals have also reported a rash on their skin.

Vaginal bleeding

During the first few weeks after taking anastrozole, it is possible to have vaginal bleeding. Most typically, it happens after switching from one hormone medication to another hormone therapy. If the bleeding persists for more than a few days, consult with a medical professional.

Changes in the liver

Occasionally, the medication anastrozole may cause changes in the way your liver functions. In most cases, they are minor and return to normal as soon as the therapy ends.


Anastrozole has the potential to produce dizziness. If you are experiencing dizziness, avoid driving. If the dizziness continues, consult your doctor.

What is the process of Anastrozole inside the body?

Anastrozole works by suppressing the synthesis of estrogen, which causes cancer cells to grow more slowly and eventually stop growing altogether. Menopausal symptoms such as hot flashes and night sweats may also be alleviated with the use of this supplement.

Anastrozole is an estrogen receptor antagonist that targets estrogen receptors in breast tissue and prevents estrogen from attaching to them. Anastrozole works by inhibiting the production of estrogen, which may stimulate the formation of some malignancies. Doing so helps to prevent tumor growth and recurrence.

The drug may also assist women under the age of five years to address some symptoms of breast cancer that have shown in their early stages. For the treatment of metastatic breast cancer, Anastrozole is permitted for use in combination with other medicines prescribed by physicians.

Take notice that this medication may also lessen the chance of developing invasive breast cancer, but it does not seem to have an effect on the risk of developing ductal carcinoma in situ (DCIS).

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What makes Anastrozole a good choice?

Anastrozole side effects

Due to the fact that it might trigger menopausal symptoms in women, Anastrozole is an excellent option for breast cancer therapy. This is caused by the reduction of estrogen to levels that are much lower than the premenopausal level, which may result in hot flashes and other symptoms. Children who are at risk for early puberty owing to illnesses such as precocious puberty or certain kinds of brain tumors have also been treated with this medication in the past.

Even though Anastrozole is not a cure for breast cancer, it may help people with endocrine-responsive breast cancer survive for a longer period of time. It is also crucial to remember that this medication does not prevent cancer from spreading or shrinking tumors in size, thus it should be used in conjunction with other cancer therapies recommended by your doctor.

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Anastrozole has been demonstrated to be successful in lowering tumor size, but it does not seem to have any influence on the length of time a cancer patient survives after being diagnosed with the disease.

Anastrozole may be administered orally or intravenously, and it does not seem to have any significant negative effects.

Benefits of Anastrozole in general

In the treatment of breast cancer, Anastrozole is a medication that may be used. It has been authorized by the Food and Drug Administration for this purpose.

Anastrozole is an aromatase inhibitor, which means that it works by lowering estrogen levels in the body, preventing cancer cells from developing and spreading. Women who have had their ovaries removed or who have not yet experienced menopause have found this medicine to be useful in the treatment of breast cancer after menopause.

The following are the primary advantages of Anastrozole:

Reduces estrogen levels in the body and inhibits the growth of cancer cells

The product is most effective for postmenopausal women who have had their ovaries removed or who have not yet gone through the menopause process.

It has been discovered to be beneficial in the treatment of postmenopausal women with breast cancer.

Is offered as an oral medication or as an injection medication.

There are no significant adverse effects associated with it.

Anastrozole is for who to take?

Who should take Anastrozole

Female breast cancer patients may use Anastrozole, which is a prescription medication that they can get from their doctor. It is intended to be taken in conjunction with other therapies that your doctor may recommend to you.

In the form of oral or injectable medications, Anastrozole may be used to treat postmenopausal women who have either had their ovaries removed or have not yet experienced the onset of menopause. In the case of breast cancer, it should not be used as a stand-alone therapy.

Anastrozole may also help lower the chance of invasive breast cancer in women who are at high risk, but it does not seem to have an effect on the risk of ductal carcinoma in situ (DCIS) in women who are not at high risk (DCIS).


Is Anastrozole a safe medication?

This selective estrogen receptor modulator has been licensed by the Food and Drug Administration for the treatment of breast cancer. It is also given to men and women for the relief of breast discomfort and swelling, respectively.

Despite the fact that Anastrozole is generally regarded as safe, there are certain potential adverse effects that you should address with your doctor before beginning to use the prescription.

Is it okay for me to take Anastrozole to bulk up?

No data exists to suggest that Anastrozole may promote muscle development. Regardless of whether you take the medicine or not, it will not assist you in gaining more muscle mass.

Neither does anastrozole affect your hormones nor does it cause you to gain any extra muscle mass. Not only does it control hormone levels, but it also has the ability to boost them.

Is it possible to purchase Anastrozole at Walmart?

Due to the fact that Anastrozole is only accessible with a prescription, you will need to get it from your doctor. There are no over-the-counter options available at typical pharmacies such as Walmart or Walgreens.

This medication is not available for purchase in many pharmacies in the United States, including Walmart and Walgreens. The only way to receive it is via a prescription from your doctor.

Is it necessary to get a prescription for Anastrozole?

Because it is not an over-the-counter drug, Anastrozole may only be obtained with a prescription from your doctor or pharmacist. Although the medicine has been authorized by the FDA for the treatment of breast cancer, it is also given for the relief of breast discomfort and swelling in both men and women.

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